Showing posts with label memory. Show all posts
Showing posts with label memory. Show all posts

Friday, November 30, 2012

Diabetes - Scrambled Brain Issues

I have this nagging suspicion that having diabetes and extra large glucose molecules floating around my vascular system may in all likelihood have a potential impact on my BRAIN. Why you ask.........

Well, for one there are definite links to dementia and vascular disease. It is also becoming obvious to me that mood and diabetes are intricately linked.  I mean I not only notice this in my own actions and moods, but now in those of my two other D kids under my direct care. 

Of course the obsessive part of me, or my brain, asks questions like; how early does the small vessel damage in the brain occur? Is it inevitable? And am I turning into this monster as I go about my day-to-day activities? Or, is it simply normal responses to everyday stresses causing my temper to flare, and my words to fly, often inappropriately, and almost always too quick for me to control.

Then there are my Kids. The ones with Diabetes of course. They are notoriously more temperamental then the other siblings. My teen is, lets just say, unbearable some days, and linked to poorly controlled sugar levels, sleep patterns, and the typical hormonal fluctuations she is unfortunately afflicted with solely based on her pubescent phase of life. Undoubtedly annoying to me nonetheless.

Back to my brain. I admit I have insurmountable domestic responsibilities. We moved again, and have just recently started a new school year at differemt schools. Sounds a lot like typical life. Changes, the ebb and flow, the usual. But is my mood, behavior, and my ability to handle stress some how worse and more difficult to manage because my small brain  (not my size, he he) vessels are being ravaged over time by the occasional elevated sugar levels?  So really, has diabetes and high sugar levels "Scrambled My Brain"

Anyone else out there in the D-sphere find that concentration, temperament, memory is effected from having diabetes for many years or at the very least when your diabetes is completely messed up.

I wrote this post a few months ago, and have since found out my thyroid was really, really low, and since taking synthroid, my memory and concentration has improved, but I still pose the above question.

Thursday, April 21, 2011

Pickled Diabetic Melon - Proof

Good Day!  I am so happy to hear from Y'all! 

As promised I did a review of some literature to check into the "Pickled Brain Syndrome" I blamed my recent act of stupidity on.  Here are a few I found to chew on.

Malone and colleagues did  a study  using rats that showed the following in support of  the “Pickled Brain” theory.
Hyperglycemia, but not hypoglycemia, was associated with adverse effects on the brain polyol pathway activity, neuronal structural changes, and impaired long-term spatial memory. This finding suggests that the hyperglycemic component of diabetes mellitus has a greater adverse effect on brain functioning than does intermittent hypoglycemia.

In other words the brains pathways involved in memory access is hampered when PWD experience high blood glucose. Gee I could have used this information years ago for all sorts of evil means.

 

Perantie and company performed a study that set out to determine whether hypoglycemia or hyperglycemia resulted in cognitive impairment in Type 1 children.

What they found was the following:
 The group with T1DM had lower estimated verbal intelligence than sibling controls. Within the T1DM group, verbal intelligence was reduced with increased exposure to Hyper, not to Hypo. In contrast, spatial intelligence and delayed recall were reduced only with repeated Hypo, particularly when Hypo episodes occurred before the age of 5 yr.

What the hell. Like we Parents want to read this.  I think I turned out okay, I managed to complete post secondary education, but I remember having “good” exams days, and “bad” exam days, and in retrospect the bad ones were the “My Sugars Out of Whack Days”

As my wife constantly says in our house, “Protect her little brain”

Sommerfield and colleagues examined a group of adult type 2 diabetics and found strikingly similar findings as the above two studies. 
Speed of information processing, working memory, and some aspects of attention were impaired during acute hyperglycemia. Subjects were significantly more dysphoric during hyperglycemia, with reduced energetic arousal and increased sadness and anxiety.
The findings above support the pickled brain syndrome. Not only memory but mood as well, which for children who are already emotionally challenged makes for a challenging scenario.   Damn high blood sugars!

Kubiak and his folks reviewed some research and discussed this the effect of post meal glucose spikes on memory.
 If you link to the publication near the end there is discussion about post meal blood sugar highs impairing memory in Type 2 Diabetes. Interesting, and something else to consider when dealing with our own management.

Article Link  - To Discussion.  

This information certainly reminds me of  the importance of maintaining tight glycemic control. Not only to prevent the typical, frequently spoken about complications we constantly hear about; blindness, vascular disease, kidney failure, feet issues, penis issues, heart disease, etc. But the "Pickled Brain" issue.


Well I wish you all a fab Easter weekend!!!

Trev

Sources:

Malone, John; Hanna, Suzan; Saporta, Samuel; Mervis, Ronald F; Park, Collin R; Chong, Ling; Diamond, David M. Hyperglycmia not hypoglycemia altners neuronal dentrites and impairs spatial memory.  Pediatric Diabetes. 9(6):531-539, December 2008.

Perantie, Dana C; Lim, Audrey; Wu, Jenny; Weaver, Patrick; Warren, Stacie L; Sadler, Michelle; White, Neil H; Hershey.   Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus.Tamara.Pediatric Diabetes. 9(2):87-95, April 2008.
Sommerfield, Andrew J. MRCP; Deary, Ian J. PHD; Frier, Brian M. MD. Acute Hyperglycemia Alters Mood State and Impairs Cognitive Performance in People With Type 2 Diabetes. Diabetes Care. 27(10):2335-2340, October 2004.

Kubiak, Thomas; Hermanns, Norbert; Preier, Michael; Kulzer, Bernhard; Haak, Thomas MD.
Memory Impairments Associated With Postprandial Hyperglycemia and Glycemic Control.
Diabetes Care. 27(2):634-635, February 2004.






Wednesday, April 20, 2011

My Pickled Diabetic Brain - Seriously!

"My brain on sugar"
First off;  Thank-you dear online friend who tipped me off to re-enable my post option to include comments.

Yes,  I feel like a big idiot.

I thought I was loosing my mind! Like maybe the stuff I've read related to having cognitive defects (brain issues) after having my melon (brain) pickled in sugar for 28 + years was finally becoming my reality.

You may,  or may not, have noticed my post earlier today, yes that one, the one about a diary, and publicly sharing thoughts, and experiences related to diabetes.

Well that my friends was a figment of your imagination. As I pull out my magic wand and erase your memories.  Just like in the movie Men in Black

If you didn't catch my earlier post today then no worries, you didn't miss a thing. Let's say it was a pickled brain thing.  

Let's just say between a higher A1C and a long SAD winter, there is still snow outside, not kidding I some how, not sure how, disabled my comments on my posts.  

Well it is now re-enabled, and I look forward to hearing from you guys, if I have any scant amount of credibility left in the DOC.

Oh, since I mentioned it; the pickled brain thing that is.  There is some research indicating us PWD do experience slower memory recall, and cognitive function when our sugars are screwed up beyond recognition.  I promise to do a legit lit review tomorrow, and write a quick post on Diabetes and Cognition.

Well, I wish you the very best!

Trev